Includes bibliographical references.
|Statement||edited by R. John Solaro and Richard L. Moss.|
|Series||Advances in muscle research -- v. 1|
|Contributions||Solaro, R. John., Moss, Richard L. Ph.D.|
|LC Classifications||QP321 .M763 2002|
|The Physical Object|
|Pagination||xi, 468 p. :|
|Number of Pages||468|
|LC Control Number||2002031646|
"Molecular Control Mechanisms in Striated Muscle Contraction addresses the molecular mechanisms by which contraction of heart and skeletal muscles is regulated, as well as the modulation of these mechanisms by important (patho)physiological variables such as ionic composition of the myoplasm and phosphorylations of contractile and regulatory proteins.". Striated or skeletal muscle is both highly specialised and very common in the vertebrate body. In this book, Professor Perry discusses and evaluates the great strides that have been taken recently to further our understanding of the molecular mechanisms and regulatory processes in both normal and diseased muscle. In the field of the molecular mechanism of contraction in striated muscle, the stepwise progress was achieved by three great investigators in \'s and \'s. In the early \'s, Albert Szent-Gyorgyi and his associates showed biochemically that muscle contraction is essentially an interaction between actin and myosin coupled with ATP hydrolysis. The book focuses on the molecular and cellular facets of skeletal muscle function. The selection first offers information on the mechanical properties of cross-bridges and their relation to muscle contraction; molecular basis of functional specialization in muscle as induced by innervation; and electrical properties of crustacean muscle membranes.
Molecular control mechanisms in muscle contraction. A Weber, and ; J M Murray; A Weber. Search for more papers by this author Molecular mechanisms in muscular contraction. Trends in Neurosciences, Vol. 6 The mechanism for vertebrate striated muscle contraction. Circulation Research, Vol. 42, No. 1. Regulatory Mechanisms of Striated Muscle Contraction. Editors (view affiliations) Setsuro Ebashi Citations; 39k Downloads; Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume ) Log in to check access. Buy eBook. USD Molecular Pathogenic Mechanisms of Cardiomyopathies Caused by Mutations in. Striated muscles and the huxley-hanson model. Striated muscles have a relatively simple morphology with no bends or curvatures but exhibit large complexity in the organization of their main molecular constituents: actin, myosin, titin, and numerous minor components, all of which form the contractile sarcomer cell schematized in Figure Figure1A 1A in the contracted state. Skeletal muscle innervation is a multi-step process leading to the neuromuscular junction (NMJ) apparatus formation. The transmission of the signal from nerve to muscle occurs at the NMJ level. The molecular mechanism that orchestrates the organization and functioning of synapses is highly complex, and it has not been completely elucidated so far.
When the sarcomeres within a muscle cell contract, the muscle itself contracts and shortens. In the accompanying animation, we examine the mechanism by which a sarcomere shortens during contraction. CONCLUSION. A muscle contraction can be explained by the cycle of molecular events that take place between actin and myosin filaments. Regulation of contraction in vertebrate striated muscle is linked to the thin filament. The initial and critical step in activation is the binding of regulatory Ca 2+ to specific sites in troponin. Molecular Control Mechanisms in Striated Muscle Contraction. The reader is directed to the following books for recent summaries of the broad Trafford A.W., Eisner D.A. () Excitation-Contraction Coupling in Cardiac Muscle. In: Solaro R.J., Moss R.L. (eds) Molecular Control Mechanisms in Striated Muscle Contraction. Advances in Muscle. González A., Ríos E. () Excitation-Contraction Coupling in Skeletal Muscle. In: Solaro R.J., Moss R.L. (eds) Molecular Control Mechanisms in Striated Muscle Contraction. Advances in Muscle .